Five year follow-up of morbidity and mortality among recipients of high-titre measles vaccines in Senegal
Identifieur interne : 006535 ( Main/Exploration ); précédent : 006534; suivant : 006536Five year follow-up of morbidity and mortality among recipients of high-titre measles vaccines in Senegal
Auteurs : Peter Aaby [Sénégal] ; Badara Samb [Sénégal] ; Francois Simondon [Sénégal] ; Kim Knudsen [Danemark] ; Awa Marie Coll Seck [Sénégal] ; John Bennett [États-Unis] ; Lauri Markowitz [États-Unis] ; Hilton Whittle [Gambie]Source :
- Vaccine [ 0264-410X ] ; 1996.
English descriptors
- Teeft :
- Aaby, Annual mortality rate, Attack rate, Beneficial effect, Child survival, Danish epidemiology science centre, Differential mortality, February, Female recipients, First years, Higher mortality, Immunization, Lower mortality, Male recipients, Measles, Measles cases, Measles immunization, Measles infection, Measles vaccination, Measles vaccine, Measles vaccines, Measles virus, Monthly cohorts, Mortality, Mortality rate ratio, Niakhar trial, Present account, Protective efficacy, Recipient, Rural senegal, Same compound, Same household, Schwarz, Schwarz measles vaccine, Secondary attack rates, Senegal, Standard vaccine, Statens seruminstitut, Study area, Surveillance system, Task force, Unimmunized children, Unvaccinated children, Vaccine, Vaccine efficacy, Vaccine eficacy.
Abstract
Abstract: At 3–5 years of age, female recipients of Edmonston-Zagreb high-titre (EZ-HT) and Schwarz high-titre (SW-HT) measles vaccine had lower survival rates than female recipients of Schwarz standard measles vaccine (SW-STD) in Guinea-Bissau, Senegal and Haiti. In Senegal, the children who received high-titre vaccines have now been followed to the age of 5–7 years to determine whether the difference in mortality persisted, and whether differences in vaccine efficacy were apparent. At this age there was no difference in mortality between female recipients of high-titre and standard titre measles vaccines. There was no indication that high-titre EZ-HT vaccine at 5 months (EZ-HT,5m) provided suboptimal protection, as vaccine efficacy after exposure was 97% and 95%, respectively, for EZ-HT,5m and SW-STD,10m vaccines, whereas SW-HT,5m vaccine had an efficacy of 81%. The difference in mortality between recipients of high-titre vaccines and SW-STD observed in several studies during the first few years after vaccination may be explained by non-specific beneficial effects of the standard measles vaccine rather than a harmful effect of the high-titre vaccines.
Url:
DOI: 10.1016/0264-410X(95)00178-4
Affiliations:
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Marie" sort="Coll Seck, Awa Marie" uniqKey="Coll Seck A" first="Awa Marie" last="Coll Seck">Awa Marie Coll Seck</name><affiliation wicri:level="1"><country xml:lang="fr">Sénégal</country><wicri:regionArea>Université Cheikh Anta Diop, Dakar</wicri:regionArea><wicri:noRegion>Dakar</wicri:noRegion></affiliation></author><author><name sortKey="Bennett, John" sort="Bennett, John" uniqKey="Bennett J" first="John" last="Bennett">John Bennett</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Task Force for Child Survival and Development, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Markowitz, Lauri" sort="Markowitz, Lauri" uniqKey="Markowitz L" first="Lauri" last="Markowitz">Lauri Markowitz</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Whittle, Hilton" sort="Whittle, Hilton" uniqKey="Whittle H" first="Hilton" last="Whittle">Hilton Whittle</name><affiliation wicri:level="1"><country xml:lang="fr">Gambie</country><wicri:regionArea>MRC Laboratories, Banjul</wicri:regionArea><wicri:noRegion>Banjul</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="226">226</biblScope><biblScope unit="page" to="229">229</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aaby</term><term>Annual mortality rate</term><term>Attack rate</term><term>Beneficial effect</term><term>Child survival</term><term>Danish epidemiology science centre</term><term>Differential mortality</term><term>February</term><term>Female recipients</term><term>First years</term><term>Higher mortality</term><term>Immunization</term><term>Lower mortality</term><term>Male recipients</term><term>Measles</term><term>Measles cases</term><term>Measles immunization</term><term>Measles infection</term><term>Measles vaccination</term><term>Measles vaccine</term><term>Measles vaccines</term><term>Measles virus</term><term>Monthly cohorts</term><term>Mortality</term><term>Mortality rate ratio</term><term>Niakhar trial</term><term>Present account</term><term>Protective efficacy</term><term>Recipient</term><term>Rural senegal</term><term>Same compound</term><term>Same household</term><term>Schwarz</term><term>Schwarz measles vaccine</term><term>Secondary attack rates</term><term>Senegal</term><term>Standard vaccine</term><term>Statens seruminstitut</term><term>Study area</term><term>Surveillance system</term><term>Task force</term><term>Unimmunized children</term><term>Unvaccinated children</term><term>Vaccine</term><term>Vaccine efficacy</term><term>Vaccine eficacy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: At 3–5 years of age, female recipients of Edmonston-Zagreb high-titre (EZ-HT) and Schwarz high-titre (SW-HT) measles vaccine had lower survival rates than female recipients of Schwarz standard measles vaccine (SW-STD) in Guinea-Bissau, Senegal and Haiti. In Senegal, the children who received high-titre vaccines have now been followed to the age of 5–7 years to determine whether the difference in mortality persisted, and whether differences in vaccine efficacy were apparent. At this age there was no difference in mortality between female recipients of high-titre and standard titre measles vaccines. There was no indication that high-titre EZ-HT vaccine at 5 months (EZ-HT,5m) provided suboptimal protection, as vaccine efficacy after exposure was 97% and 95%, respectively, for EZ-HT,5m and SW-STD,10m vaccines, whereas SW-HT,5m vaccine had an efficacy of 81%. The difference in mortality between recipients of high-titre vaccines and SW-STD observed in several studies during the first few years after vaccination may be explained by non-specific beneficial effects of the standard measles vaccine rather than a harmful effect of the high-titre vaccines.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Gambie</li><li>Sénégal</li><li>États-Unis</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Sénégal"><noRegion><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name></noRegion><name sortKey="Coll Seck, Awa Marie" sort="Coll Seck, Awa Marie" uniqKey="Coll Seck A" first="Awa Marie" last="Coll Seck">Awa Marie Coll Seck</name><name sortKey="Samb, Badara" sort="Samb, Badara" uniqKey="Samb B" first="Badara" last="Samb">Badara Samb</name><name sortKey="Simondon, Francois" sort="Simondon, Francois" uniqKey="Simondon F" first="Francois" last="Simondon">Francois Simondon</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Knudsen, Kim" sort="Knudsen, Kim" uniqKey="Knudsen K" first="Kim" last="Knudsen">Kim Knudsen</name></region></country><country name="États-Unis"><noRegion><name sortKey="Bennett, John" sort="Bennett, John" uniqKey="Bennett J" first="John" last="Bennett">John Bennett</name></noRegion><name sortKey="Markowitz, Lauri" sort="Markowitz, Lauri" uniqKey="Markowitz L" first="Lauri" last="Markowitz">Lauri Markowitz</name></country><country name="Gambie"><noRegion><name sortKey="Whittle, Hilton" sort="Whittle, Hilton" uniqKey="Whittle H" first="Hilton" last="Whittle">Hilton Whittle</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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